Molecular Evolution of Human Coronavirus Genomes

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• 作者：Diego Forni¹ ; Rachele Cagliani¹ ; Mario Clerici² ; ³ ; Manuela Sironi¹ ; ^{manuela.sironi@bp.lnf.it}
• 关键词：human coronavirus ; molecular evolution ; gene gain/loss ; positive selection ; recombination ; host shift
• 刊名：Trends in Microbiology
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：25
• 期：1
• 页码：35-48
• 全文大小：3273 K
• 卷排序：25

文摘

Human coronaviruses (HCoVs), including SARS-CoV and MERS-CoV, are zoonotic pathogens that originated in wild animals. HCoVs have large genomes that encode a fixed array of structural and nonstructural components, as well as a variety of accessory proteins that differ in number and sequence even among closely related CoVs. Thus, in addition to recombination and mutation, HCoV genomes evolve through gene gains and losses. In this review we summarize recent findings on the molecular evolution of HCoV genomes, with special attention to recombination and adaptive events that generated new viral species and contributed to host shifts and to HCoV emergence.Video AbstractTo view the video inline, enable JavaScript on your browser. However, you can download and view the video by clicking on the icon belowHelp with MP4 filesOptionsDownload video (16580 K)