Complete genome sequence of sequential Pandoraea apista isolates from the same cystic fibrosis patient supports a model of chronic colonization with in vivo strain evolution over time

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• 作者：Alexander L. Greninger^a ; ^b ; ^c ; Jessica Streithorst^a ; Jeffrey A. Golden^d ; Charles Y. Chiu^a ; ^b ; ^e ; Steve Miller^a ; ^b ; ^{steve.miller@ucsf.edu}
• 关键词：Pandoraea apista ; Genome sequence ; Strain evolution
• 刊名：Diagnostic Microbiology and Infectious Disease
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：87
• 期：1
• 页码：1-6
• 全文大小：954 K
• 卷排序：87

文摘

Complete genome sequence was obtained for 3 P. apista isolates. P. apista genomes demonstrate several novel loci. Genome comparison indicates chronic colonization in the cystic fibrosis lung niche. These bacteria accumulate approximately 100 mutations per year in vivo.