Processing of the abasic sites clustered with the benzo[a]pyrene adducts by the base excision repair enzymes

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• 作者：Lidia V. Starostenko^a ; ^b ; ¹ ; Nadejda I. Rechkunova^a ; ¹ ; Natalia A. Lebedeva^a ; ^b ; Alexander A. Lomzov^a ; ^b ; Vladimir V. Koval^a ; ^b ; Olga I. Lavrik^a ; ^b ; ^{lavrik@niboch.nsc.ru}
• 关键词：Base excision repair ; Apurinic/apyrimidinic endonuclease 1 ; DNA polymerases ; Benzo[a]pyrene ; Clustered lesions
• 刊名：DNA Repair
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：50
• 期：Complete
• 页码：43-53
• 全文大小：3557 K
• 卷排序：50

文摘

We examine the structure of APE1 complex with DNA containing clustered damages. Relative positions of AP site and B[a]P adduct have high impact in the APE1 active center geometry. Polβ inhibits the 3′ → 5′ exonuclease activity of APE1. Functional cooperation of APE1 and Polβ in the base excision repair is demonstrated.