Co-expression of TIM-3 and CEACAM1 promotes T cell exhaustion in colorectal cancer patients

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• 作者：Yang Zhang^a ; Pengcheng Cai^a ; Lei Li^b ; Liang Shi^b ; Panpan Chang^c ; Tao Liang^a ; Qianqian Yang^a ; Yang Liu^a ; Lin Wang^a ; ^d ; ^{katelinwang@126.com} ; Lihua Hu^a ; ^{lihuahu@hust.edu.cn}
• 关键词：TIM-3 ; T-cell immunoglobulin domain and mucin domain-3 ; CEACAM1 ; carcinoembryonic antigen cell adhesion molecule 1 ; CRC ; colorectal cancer ; TIL ; tumor infiltrating lymphocytes ; CEA ; carcinoembryonic antigen
• 刊名：International Immunopharmacology
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：43
• 期：Complete
• 页码：210-218
• 全文大小：1478 K
• 卷排序：43

文摘

Identification of two potential immuno-markers for colorectal cancer. Their co-expression mediates T cell exhaustion and promotes cancer progression. The connection between markers and clinical features implies for targeted therapy.