Differential activation of noncanonical SMAD2/SMAD3 signaling by bone morphogenetic proteins causes disproportionate induction of hyaluronan production in immortalized human granulosa cells
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- 作者：Han Zhanga ; b ; 1 ; Shen Tiana ; c ; 1 ; Christian Klausena ; Hua Zhua ; Ruizhi Liub ; lrz420@126.com" class="auth_mail" title="E-mail the corresponding author ; Peter C.K. Leunga ; peter.leung@ubc.ca" class="auth_mail" title="E-mail the corresponding author
- 关键词：BMP ; HAS2 ; Hyaluronan ; SMAD1/5/8 ; SMAD3 ; SMAD2 ; Human granulosa cell
- 刊名：Molecular and Cellular Endocrinology
- 出版年：2016
- 出版时间：15 June 2016
- 年：2016
- 卷：428
- 期：Complete
- 页码：17-27
- 全文大小：2280 K
文摘
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Human granulosa cells were used to explore the roles of BMPs in cumulus expansion-related gene expression.
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BMP4, BMP6, BMP7 and BMP15 differentially induce HAS2 and hyaluronan production.
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These effects result from differential activation of noncanonical SMAD2/3 signaling.
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Activation of SMAD2/3 signaling requires BMP and activin/TGF-β type I receptors.
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We show that BMPs can exert different functions via different SMAD signaling.