Anesthetics inhibit extracellular signal-regulated Kinase1/2 phosphorylation via NMDA receptor, phospholipase C and protein kinase C in mouse hippocampal slices

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• 作者：Gao Haiying^a ; Han Mingjie^a ; Zhang Lingyu^a ; Wang Qingxiang^a ; Wang Haisong^a ; Zhang Bingxi^b ; ^{zbxtryy@126.com}
• 关键词：Anesthetics ; Extracellular signal-regulated Kinase1/2 ; Phosphorylation ; Hippocampus ; Phospholipase C ; Protein kinase C
• 刊名：Neurochemistry International
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：103
• 期：Complete
• 页码：36-44
• 全文大小：1797 K
• 卷排序：103

文摘

Propofol, etomidate, ketamine and midazolam reduced ERK1/2 phosphorylation. The reduction in phosphorylation is in a time-dependent manner. The decreased phosphorylation is blocked via NMDA, PLC inhibitor and PKC activator. The inhibition of propofol was potentiated by PKC- and MEK- inhibitor and PLC activator. ERK1/2 represents a target for anesthetics in the brain.