rLj-RGD3 induces apoptosis via the mitochondrial-dependent pathway and inhibits adhesion, migration and invasion of human HeyA8 cells via FAK pathway

详细信息    查看全文

• 作者：Qi Jiang^a ; ^b ; ¹ ; Qingwei Li^a ; ^b ; ¹ ; Jianmei Han^a ; ^b ; Meng Gou^a ; ^b ; Yuanyuan Zheng^a ; ^b ; Bowen Li^a ; ^b ; Rong Xiao^a ; ^b ; ^{liulangmao1980@126.com} ; Jihong Wang^a ; ^b ; ^{y.y.200@163.com}
• 关键词：BCA ; bicinchoninic acid ; bFGF ; basic fibroblast growth factor ; BSA ; bovine serum albumin ; caspase ; cysteine-aspartic acid protease ; DCFH-DA ; 2&prime ; 7&prime ; -dichloroflurescin- diacetate ; DMEM ; dulbecco's modified eagle medium ; ECM ; extracellular matrix ; E. coli ; Escherichia coli ; EDTA ; ethylenediaminetetraacetic acid ; ERK ; extracellular signal-regulated kinase ; FAK ; focal adhesion kinase ; FBS ; fetal bovine serum ; GAPDH ; glyceraldehyde-3-phosphate dehydrogenase ; HPLC ; high performance liquid c
• 刊名：International Journal of Biological Macromolecules
• 出版年：2017
• 出版时间：March 2017
• 年：2017
• 卷：96
• 期：Complete
• 页码：652-668
• 全文大小：7529 K
• 卷排序：96

文摘

This report represents the anti-tumor effects of rLj-RGD3 without a His-tag cloned from lampreys on ovarian carcinoma (HeyA8 cells) for the first time. This report clarifies the anti-tumor mechanisms of rLj-RGD3 on ovarian carcinoma (HeyA8 cells). This report provides important information for the treatment of ovarian carcinoma by rLj-RGD3.