A critical role for ChREBP-mediated FGF21 secretion in hepatic fructose metabolism

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• 作者：ffolliott M. Fisher¹ ; MiSung Kim¹ ; Ludivine Doridot¹ ; Jeremy C. Cunniff¹ ; Thomas S. Parker² ; Daniel M. Levine² ; Marc K. Hellerstein³ ; Lisa C. Hudgins² ; Eleftheria Maratos-Flier¹ ; ^{emaratos@bidmc.harvard.edu} ; Mark A. Herman¹ ; ⁴ ; ^{mark.herman@duke.edu}
• 关键词：FGF21 ; ChREBP ; Fructose ; Lipogenesis ; NAFLD
• 刊名：Molecular Metabolism
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：6
• 期：1
• 页码：14-21
• 全文大小：1092 K
• 卷排序：6

文摘

ChREBP is required for fructose-induced increases in circulating FGF21. Fructose-induced FGF21 feeds back on the liver to enhance ChREBP activity, lipogenesis, VLDL secretion, and fatty liver. Circulating FGF21 correlates with rates of de novo lipogenesis in human subjects. In the setting of high-fructose feeding, FGF21 protects the liver against inflammation and fibrosis.