Heartbeat-related distension and displacement of the thoracic aorta in healthy volunteers

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• 作者：Fabian Rengier^a ; ^b ; ¹ ; ² ; ^{f.rengier@dkfz.de} ; Tim Frederik Weber^b ; ^a ; ¹ ; ² ; ^{Tim.Weber@med.uni-heidelberg.de} ; Verena Henninger^a ; ^b ; ¹ ; ² ; ^{Verena.Henninger@web.de} ; Dittmar Bö ; ckler^c ; ³ ; ^{dboeckler@me.com} ; Hardy Schumacher^d ; ⁴ ; ^{Hardy_Schumacher@klinikum-hanau.de} ; Hans-Ulrich Kauczor^b ; ² ; ^{Hans-Ulrich.Kauczor@med.uni-heidelberg.de} ; Hendrik von Tengg-Kobligk^b ; ^a ; ^{hardyschumacher@web.de}
• 关键词：Thoracic aorta ; Physiology ; Stent graft ; Endovascular ; Magnetic resonance imaging
• 刊名：European Journal of Radiology
• 出版年：2012
• 出版时间：January 2012
• 年：2012
• 卷：81
• 期：1
• 页码：158-164
• 全文大小：656 K

文摘

Purpose

To test our hypothesis that distension and displacement in various segments of the healthy thoracic aorta are significant and can be predicted based on clinical characteristics.

Materials and methods

Sixty-one Caucasian volunteers without cardiovascular disease (49 ¡À 16 years, range 19-82; 28 men, 33 women) divided into two age groups (A: <50, B: ?0 years) underwent 1.5-T MRI. ECG-gated dynamic data sets were acquired at five locations perpendicular to the thoracic aorta. Aortic distension and Centre of Mass (CoM) displacement were determined as percentages of diastolic aortic diameter. A multiple linear regression model including age group, gender, location, mean arterial blood pressure, heart rate and body mass index was tested.

Results

Mean aortic distension averaged over all locations was 11.2 ¡À 4.1 % (age group A) and 6.7 ¡À 3.3 % (age group B), mean displacement 15.1 ¡À 8.3 % (A) and 11.0 ¡À 6.2 % (B). Systolic and diastolic aortic diameter and CoM position significantly differed at all locations (p < 0.001). Distension and displacement could be predicted based on the regression model (p < 0.001). Age group A and women exhibited significantly greater distension and displacement compared to age group B (p < 0.001) and men (p < 0.01), respectively. Distension increased, displacement decreased from proximal to distal.

Conclusion

Distension and translational displacement are significant at all levels of the thoracic aorta and can be predicted based on clinical characteristics.