Exosome-Transmitted lncARSR Promotes Sunitinib Resistance in Renal Cancer by Acting as a Competing Endogenous RNA
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- 作者：Le Qu1 ; 10 ; Jin Ding2 ; 10 ; Cheng Chen2 ; 3 ; 10 ; Zhen-Jie Wu1 ; 10 ; Bing Liu1 ; 10 ; Yi Gao1 ; Wei Chen1 ; Feng Liu4 ; Wen Sun2 ; Xiao-Feng Li2 ; Xue Wang2 ; Yue Wang5 ; Zhen-Yu Xu5 ; Li Gao6 ; Qing Yang7 ; Bin Xu7 ; Yao-Ming Li7 ; Zi-Yu Fang7 ; Zhi-Peng Xu1 ; Yi Bao1 ; Deng-Shuang Wu1 ; Xiong Miao8 ; Hai-Yang Sun9 ; Ying-Hao Sun7 ; Hong-Yang Wang2 ; hywangk@vip.sina.com" class="auth_mail" title="E-mail the corresponding author ; Lin-Hui Wang1 ; wanglinhuicz@163.com" class="auth_mail" title="E-mail the corresponding author
- 刊名：Cancer Cell
- 出版年：2016
- 出版时间：9 May 2016
- 年：2016
- 卷：29
- 期：5
- 页码：653-668
- 全文大小：6561 K
文摘
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lncARSR promotes sunitinib resistance and predicts poor response of RCC patients
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Intercellular transfer of lncARSR by exosomes disseminates sunitinib resistance
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lncARSR acts as a ceRNA for miR-34 and miR-449 to promote AXL and c-MET expression
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Targeting lncARSR or AXL/c-MET in sunitinib-resistant RCC restores drug sensitivity
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