MicroRNA-455-3p modulates cartilage development and degeneration through modification of histone H3 acetylation
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- 作者：Weishen Chen ; M.D.a ; 1 ; Lingwu Chen ; M.D. ; PHDb ; 1 ; Ziji Zhang ; M.D. ; PHDa ; Fangang Meng ; M.D.a ; Guangxin Huang ; M.D.a ; Puyi Sheng ; M.D. ; PHDa ; Zhiqi Zhang ; M.D. ; PHDa ; zhzhiqi@mail.sysu.edu.cn" class="auth_mail" title="E-mail the corresponding author ; Weiming Liao ; M.D. ; PHDa ; liaowmsysu@163.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：miR ; microRNA ; HDAC ; histone deacetylase ; OA ; osteoarthritis ; COL2A1 ; collagen 2 ; SOX9 ; SRY (sex-determining region Y)-box 9 ; RUNX2 ; Runt-related transcription factor 2 ; HAT ; histone acetyltransferase ; TSA ; trichostatin A ; Mmp13 ; matrix metalloproteinase 13 ; ITS ; [insulin (10 ; μg/ml) ; transferrin (10 ; μg/ml) ; and sodium selenite (3 ; × ; ; 10&minus ; ; 8 ; M)] ; PMCs ; primary mouse chondrocytes ; siRNA ; small interfering RNA
- 刊名：Biochimica et Biophysica Acta (BBA)-Molecular Cell Research
- 出版年：2016
- 出版时间：December 2016
- 年：2016
- 卷：1863
- 期：12
- 页码：2881-2891
- 全文大小：2343 K
文摘
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miR-455-3p targets and inhibits HDAC2 and HDAC8 during chondrogenesis.
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miR-455-3p promotes chondrogenesis by enhancing histone H3 acetylation.
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Inhibiting HDAC2/8 enhances chondrogenesis and prevents degeneration.