Urinary N-Acetyl-β--glucosaminidase Isoenzymes as Biomarker of Renal Dysfunction Caused by Cadmium in a General Population

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• 作者：Jin ; Taiyi ; Nordberg ; Gunnar ; Wu ; Xunwei ; Ye ; Tingting ; Kong ; Qinghu ; Wang ; Zaijuan ; Zhuang ; Fangchen ; et. al.
• 刊名：Environmental Research
• 出版年：1999
• 出版时间：August, 1999
• 年：1999
• 卷：81
• 期：2
• 页码：167-173
• 全文大小：136 K

文摘

N-Acetyl-β-D-glucosaminidase (NAG) and its isoenzymes in urine have been studied in a population group residing in a polluted area in China. The area studied was contaminated by industrial wastewater from a nearby smelter that discharged cadmium-polluted wastewater into a river used for the irrigation of rice fields. Cadmium concentrations in rice were 3.70, 0.51, and 0.07 mg/kg for the highly and moderately polluted areas and the control area, respectively. Cadmium concentrations in urine exceeded 5 μg/liter in the majority of subjects in the most highly polluted area. There was a marked dose-dependent increase in NAG and NAG B content of urine related both to urinary cadmium and to the calculated cadmium uptake. It is concluded that urinary NAG and its isoenzymes could serve as a sensitive biomarker of renal dysfunction in cadmium-exposed populations. The mechanisms underlying the increase in NAG and its isoenzymes after cadmium exposure need to be studied further.