Cardiopulmonary protective effects of the selective FXR agonist obeticholic acid in the rat model of monocrotaline-induced pulmonary hypertension

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• 作者：Linda Vignozzi^a ; Annamaria Morelli^b ; Ilaria Cellai^a ; Sandra Filippi^c ; Paolo Comeglio^a ; Erica Sarchielli^b ; Elena Maneschi^a ; Gabriella Barbara Vannelli^b ; Luciano Adorini^d ; Mario Maggi^a ; ^e ; ^{mario.maggi@unifi.it}
• 关键词：ACE2 ; angiotensin-converting enzyme 2 ; Ach ; acetylcholine ; BA ; bile acid ; BMP2 ; bone morphogenetic protein 2 ; BMPR1A ; bone morphogenetic protein receptor 1-a ; BW ; body weight ; CDCA ; chenodeoxycholic acid ; cGMP ; cyclic guanosine monophosphate ; COX2 ; cyclooxygenase-2 ; ECs ; endothelial cells ; ET-1 ; endothelin-1 ; ETA ; endothelin receptor type A ; ETB ; endothelin receptor type B ; FXR ; farnesoid X receptor ; GCSa3 ; guanylate cyclase subunit type 1a3 ; GCSb3 ; guanylate cyclase subunit type 1b3 ; IL-1β ; int
• 刊名：The Journal of Steroid Biochemistry and Molecular Biology
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：165
• 期：part_PB
• 页码：277-292
• 全文大小：4194 K
• 卷排序：165

文摘

FXR activation is able to suppress the inflammatory response after lung injury. OCA treatment attenuated the MCT-induced pathogenic inflammatory mechanisms. OCA treatment induced profound beneficial effects on lung histology. MCT significantly reduced the treadmill endurance, which is normalized by OCA. OCA can restore the balance between relaxant and contractile pathways in the lung.