Identification of the immunogenic epitopes of the whole venom component of the Hemiscorpius lepturus scorpion using the phage display peptide library

详细信息    查看全文

• 作者：Roghaye Jahdasani^a ; ^b ; Fatemeh Rahimi Jamnani^c ; ^d ; Mahdi Behdani^a ; Mahdi Habibi-Anbouhi^e ; Najmeh Yardehnavi^f ; ^g ; Delavar Shahbazzadeh^a ; ^{shahbazzadeh@pasteur.ac.ir} ; Fatemeh Kazemi-Lomedasht^a ; ^{fa_kazemi@pasteur.ac.ir}
• 关键词：Hemiscorpius lepturus ; Epitope mapping ; Phage display peptide library ; Epitopic vaccine
• 刊名：Toxicon
• 出版年：2016
• 出版时间：15 December 2016
• 年：2016
• 卷：124
• 期：Complete
• 页码：83-93
• 全文大小：1953 K
• 卷排序：124

文摘

Phage displayed peptide library was used to assess the antigenic epitopes of Hemiscorpius lepturus toxins. Over 125 individual clones carrying mimotopes of Hemiscorpius lepturus toxins were identified. Results of this study provide a basis for development of putative epitopic vaccine as well as recombinant toxins.