Galanin system is an accepted target for development of new antidepressants.
Some data suggest that current antidepressants could act via the galanin system.
Venlafaxine is one of the most effective current antidepressants.
Venlafaxine did not alter expression of galanin, GalR1–3 receptors or alarin.
Selective modulations of the galanin system remain promising targets.
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