Heterogeneity of grade 3 gastroenteropancreatic neuroendocrine carcinomas: New insights and treatment implications
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- 作者：Nicola Fazio<sup>asup><sup> ; sup><sup>1sup><sup> ; sup><sup>nicola.fazio@ieo.it" class="auth_mail" title="E-mail the corresponding authorsup> ; Massimo Milione<sup>bsup><sup> ; sup><sup>1sup><sup> ; sup><sup>massimo.milione@istitutotumori.mi.it" class="auth_mail" title="E-mail the corresponding authorsup>
- 关键词：Neuroendocrine carcinoma ; Morphology ; Proliferation ; Classification ; Prognosis ; Therapy ; GEP
- 刊名：Cancer Treatment Reviews
- 出版年：2016
- 出版时间：November 2016
- 年：2016
- 卷：50
- 期：Complete
- 页码：61-67
- 全文大小：623 K
文摘
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G3 GEP NECs are more heterogeneous than expected according to WHO classification.
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6 studies investigating large series of G3 GEP-NECs have been published.
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Tumor morphology and Ki-67 emerged as potential prognostic factors.
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This has important prognostic and therapeutic implications.