DHEA-induced modulation of renal gluconeogenesis, insulin sensitivity and plasma lipid profile in the control- and dexamethasone-treated rabbits. Metabolic studies
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- 作者：Anna Kiersztan ; akiersztan@biol.uw.edu.pl" class="auth_mail" title="E-mail the corresponding author ; Andrzej Nagalski ; Paweł Nalepa ; Aleksandra Tempes ; Nina Trojan ; Michał Usarek ; Adam K. Jagielski
- 关键词：Dexamethasone phosphate (dexP) ; Dehydroepiandrosterone (DHEA) ; Glucocorticoids (GCs) ; Cortisol ; Renal gluconeogenesis ; G6Pase ; FBPase
- 刊名：Biochimie
- 出版年：2016
- 出版时间：February 2016
- 年：2016
- 卷：121
- 期：Complete
- 页码：87-101
- 全文大小：894 K
文摘
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DexP enhances gluconeogenesis in rabbit kidney due to increased FBPase activity.
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In vivo DexP induces the insulin resistance and high plasma cholesterol and TG levels.
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Inhibition by DHEA of renal G6Pase might be responsible for its hypoglycemic action.
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Testosterone may contribute to the DHEA-induced increase in insulin sensitivity.
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Supplementation of DHEA might be beneficial for the therapy of GCs-treated patients.