Fc gamma receptor IIIa polymorphism is not associated with susceptibility to systemic lupus erythematosus in Brazilian patients

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• 作者：Marcelle Grecco ; Viviane Cardoso dos Santos ; Kaline Medeiros Costa Pereira ; Luí ; s Eduardo Coelho Andrade ; Neusa Pereira da Silva ; ^{npsilva@unifesp.br}
• 关键词：Systemic lupus erythematosus ; Fc gamma receptor IIIa ; Single nucleotide polymorphism ; Gene polymorphism ; Immunogenetics
• 刊名：Revista Brasileira de Reumatologia (English Edition)
• 出版年：2016
• 出版时间：November-December 2016
• 年：2016
• 卷：56
• 期：6
• 页码：515-520
• 全文大小：607 K
• 卷排序：56

文摘

We evaluated the possible association between FCGR3A V/F (158) polymorphism and SLE susceptibility and clinical phenotype in 305 sequentially retrieved SLE patients and 300 healthy controls from the southeastern part of Brazil by allele-specific polymerase chain reaction. Our results showed no association between FCGR3A 158V/F alleles and susceptibility to SLE in this series of patients albeit the heterozygous genotype was strongly associated with the disease.