Structure and Function Analysis of an Antibody Recognizing All Influenza A Subtypes
详细信息 查看全文
- 作者：Nicole L. Kallewaard1 ; 8 ; Davide Corti2 ; 8 ; Patrick J. Collins3 ; 8 ; Ursula Neu3 ; 8 ; Josephine M. McAuliffe1 ; Ebony Benjamin1 ; Leslie Wachter-Rosati1 ; Frances J. Palmer-Hill1 ; Andy Q. Yuan4 ; Philip A. Walker5 ; Matthias K. Vorlaender3 ; Siro Bianchi2 ; Barbara Guarino2 ; Anna De Marco2 ; Fabrizia Vanzetta2 ; Gloria Agatic2 ; Mathilde Foglierini6 ; Debora Pinna6 ; Blanca Fernandez-Rodriguez6 ; Alexander Fruehwirth6 ; Chiara Silacci6 ; Roksana W. Ogrodowicz5 ; Stephen R. Martin5 ; Federica Sallusto6 ; JoAnn A. Suzich1 ; Antonio Lanzavecchia6 ; 7 ; 9 ; Qing Zhu1 ; 9 ; zhuq@medimmune.com" class="auth_mail" title="E-mail the corresponding author ; Steven J. Gamblin3 ; 9 ; John J. Skehel3 ; 9 ; john.skehel@crick.ac.uk" class="auth_mail" title="E-mail the corresponding author
- 刊名：Cell
- 出版年：2016
- 出版时间：28 July 2016
- 年：2016
- 卷：166
- 期：3
- 页码：596-608
- 全文大小：3373 K
文摘
- •
Binding to all influenza A subtypes neutralizing seasonal and pandemic strains
- •
Utilizes a rare VH (VH6-1) and carries a low level of somatic mutations
- •
Highly conserved epitope encompassing fusion peptide and hydrophobic groove
- •
Superior therapeutic window compared to oseltamivir in animals