In-line coupling of an achiral-chiral column to investigate the enantioselective in vitro metabolism of the pesticide Fenamiphos by human liver microsomes
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- 作者：Nayara Cristina Perez de Albuquerque ; Juliana Vicentin de Matos ; Anderson Rodrigo Moraes de Oliveira ; deoliveira@usp.br" class="auth_mail" title="E-mail the corresponding author ; armdeoliveira@gmail.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Pesticide ; Chiral analysis ; In vitro metabolism ; Human liver microsomes ; Metabolites ; Predicted toxicokinetic parameters
- 刊名：Journal of Chromatography A
- 出版年：2016
- 出版时间：7 October 2016
- 年：2016
- 卷：1467
- 期：Complete
- 页码：326-334
- 全文大小：966 K
文摘
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Simultaneous chiral analysis of fenamiphos, fenamiphos sulfoxide, fenamiphos sulfone.
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The fastest method for the chiral analysis of fenamiphos and its metabolites.
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In vitro human metabolism of rac-fenamiphos, (+)- and (−)-fenamiphos was established.
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Predict elimination of fenamiphos by CYP450 enzymes was not enantioselective.