Reveal the molecular signatures of hepatocellular carcinoma with different sizes by iTRAQ based quantitative proteomics
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- 作者：Yingchao Wanga ; b ; Hongzhi Liua ; b ; c ; Dong Lianga ; b ; c ; Yao Huanga ; b ; c ; Yongyi Zenga ; b ; c ; Xiaohua Xinga ; b ; Jiangbao Xiaa ; b ; Minjie Lina ; b ; Xiao Hand ; Naishun Liaoa ; b ; Xiaolong Liua ; b ; xiaoloong.liu@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Jingfeng Liua ; b ; c ; drjingfeng@126.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Hepatocellular carcinoma ; Quantitative proteomics ; Tumor size ; Tumor growth ; iTRAQ
- 刊名：Journal of Proteomics
- 出版年：2017
- 出版时间：6 January 2017
- 年：2017
- 卷：150
- 期：Complete
- 页码：230-241
- 全文大小：1441 K
文摘
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The iTRAQ approach was applied to study the hepatocellular carcinoma (HCC) with different sizes.
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Protein alternations were proved in the HCC comparing to noncancerous tissues.
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Different molecular alternations and specific signalings were involved in different HCC subtypes.
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A group of proteins correlated with the tumor size, which might be potential targets for study tumor growth of HCC.