Effects of arteannuin B, arteannuic acid and scopoletin on pharmacokinetics of artemisinin in mice

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• 作者：Chao Zhang ; Mu-Xin Gong ; Feng Qiu ; Jing Li ; Man-Yuan Wang ; ^{wangmyjun@163.com" class="auth_mail" title="E-mail the corresponding author}
• 关键词：Artemisinin ; Arteannuin B ; Arteannuic acid ; Scopoletin ; Pharmacokinetics
• 刊名：Asian Pacific Journal of Tropical Medicine
• 出版年：2016
• 出版时间：July 2016
• 年：2016
• 卷：9
• 期：7
• 页码：677-681
• 全文大小：396 K

文摘

To explore the effects of arteannuin B, arteannuic acid and scopoletin on the pharmacokinetics of artemisinin in mice.

Methods

Artemisinin and a combination of artemisinin, arteannuin B, arteannuic acid and scopoletin were administered together to mice via oral administration. Blood samples were collected at different time intervals and pretreated by liquid–liquid extraction. The contents of four compounds in mouse plasma were determined by a validated HPLC-MS/MS method.

Results

Compared to single artemisinin group, the C_max values from the combination group rose from 947 ng/mL to 1 254 ng/mL. AUC_(0-t) (2 371 h ng/mL) was significantly higher than that from single artemisinin group (747 h ng/mL). The peak time lag and the CL values reduced at a proportion of 66%.

Conclutions

Arteannuin B, arteannuic acid and scopoletin can markedly affect the pharmacokinetics of artemisinin.