Curcumin inhibits microglia inflammation and confers neuroprotection in intracerebral hemorrhage
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- 作者：Zhao Yanga ; 1 ; Tianzhi Zhaob ; 1 ; Yongjie Zoua ; John H. Zhanga ; Hua Fenga ; fenghua8888@vip.163.com" class="auth_mail
- 关键词：Curcumin ; Microglia ; Intracerebral hemorrhage
- 刊名：Immunology Letters
- 出版年：July 2014
- 年：2014
- 卷：160
- 期：1
- 页码：89-95
- 全文大小：1818 K
文摘
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Curcumin prevents ICH-induced inflammatory molecules through NF-魏B activation via the p38MAPK/PKC pathway in vitro.
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Curcumin protects hippocampal HT22 cells from indirect toxicity mediated by ICH-treated microglial cells.
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Curcumin attenuates ICH-induced neurological deficit and cerebral water content in vivo.
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Curcumin represent a novel herbal sources for ICH therapeutical strategy.