Preparation and characterization of cefquinome sulfate microparticles for transdermal delivery by negative-pressure cavitation antisolvent precipitation
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- 作者：Xinxuan Du1 ; Suchong Zu1 ; Fengli Chen ; Zaizhi Liu ; Xinran Li ; Lei Yang ; yanglei@nefu.edu.cn" class="auth_mail" title="E-mail the corresponding author ; Yuangang Zu ; Xiuhua Zhao ; xiuhuazhao@nefu.edu.cn" class="auth_mail" title="E-mail the corresponding author ; Lin Zhang
- 关键词：Cefquinome sulfate ; Microparticle ; Negative-pressure cavitation antisolvent precipitation ; Preparation ; Transdermal delivery
- 刊名：Powder Technology
- 出版年：2016
- 出版时间：June 2016
- 年：2016
- 卷：294
- 期：Complete
- 页码：429-436
- 全文大小：1413 K
文摘
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Micronized cefquinome sulfate was prepared by negative antisolvent precipitation.
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Micronized cefquinome sulfate with a MPS of 415.8 nm was obtained at a yield of 78%.
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Transdermal absorbability of crystalline cefquinome sulfate improved significantly.