Differences in the associations of PA and SB with HRQoL were mostly related to domain-specific PA and SB.
Associations between Leisure-time PA and HRQoL was positively cumulative and bidirectional.
Associations between screen-viewing time or total sitting time and HRQoL were negatively cumulative and bidirectional.
Not all domains of SB were negatively associated with HRQoL, reading time was found to be positively associated with HRQoL.