Congenital Cytomegalovirus among Children with Cerebral Palsy

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• 作者：Hayley Smithers-Sheedy ; PhD¹ ; ² ; ³ ; Camille Raynes-Greenow ; PhD⁴ ; Nadia Badawi ; PhD² ; ³ ; Marian A. Fernandez ; PhD¹ ; ² ; ^* ; Alison Kesson ; PhD¹ ; ² ; Sarah McIntyre ; PhD³ ; ⁵ ; Kin-Chuen Leung ; PhD² ; Cheryl A. Jones ; PhD¹ ; ² ; ^{cheryl.jones@health.nsw.gov.au}
• 关键词：disability ; registry ; newborn screening ; neurotropic ; virus ; development
• 刊名：The Journal of Pediatrics
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：181
• 期：Complete
• 页码：267-271.e1
• 全文大小：268 K
• 卷排序：181

文摘

To determine the proportion of children with cerebral palsy (CP) and cytomegalovirus (CMV) DNA detected retrospectively in their newborn screening cards (NBSC), to compare the proportion of children with CMV DNA in their NBSC across spastic subtypes of CP, and to compare the sex and other characteristics of children with CP and CMV detected on their NSBC with those in whom CMV DNA was not detected.Study designRetrospective observational study. Data were extracted from patient records on children with CP (birth years 1996-2014) from 2 Australian state CP registers and state-wide paediatric rehabilitation services with consent. NBSCs were retrospectively analyzed for CMV DNA by nested polymerase chain reaction (PCR) using primers against gB. Positive samples were validated using real time PCR for CMV UL83.ResultsOf 401 children recruited, 323 (80.5%) had an available NBSC. Of these, 31 (9.6%; 95% CI, 6.8-13.3) tested positive for CMV DNA by nested PCR for CMV gB, of whom 28 (8.7%; 95% CI, 6.1-12.2) also had CMV DNA detected by real-time PCR for CMV UL83. Detection of CMV DNA was significantly associated with epilepsy, but not with clinical or epidemiologic characteristics, including sex and pattern of spasticity.ConclusionsCMV viremia in the newborn period, indicating congenital CMV infection, is highly prevalent among children with CP. Further research is needed to investigate the mechanisms and contribution of congenital CMV to the causal pathways to CP.