Mitotic Nuclear Envelope Breakdown and Spindle Nucleation Are Controlled by Interphase Contacts between Centromeres and the Nuclear Envelope

详细信息    查看全文

• 作者：Alfonso Ferná ; ndez-Á ; lvarez¹ ; ² ; ^{alfonso.fernandezalvarez@nih.gov} ; Cé ; cile Bez² ; ⁴ ; Eileen T. O'Toole³ ; Mary Morphew³ ; Julia Promisel Cooper¹ ; ² ; ⁵ ; ^{julie.cooper@nih.gov}
• 关键词：centromere ; centrosome ; telomere ; nuclear envelope breakdown ; mitosis ; cell cycle ; meiosis ; spindle pole body ; fission yeast ; chromatin
• 刊名：Developmental Cell
• 出版年：2016
• 出版时间：5 December 2016
• 年：2016
• 卷：39
• 期：5
• 页码：544-559
• 全文大小：6744 K
• 卷排序：39

文摘

Mitotic and meiotic spindle formation require prior chromosome-LINC contact Sad1.2 maintains LINC stability but destroys interphase centromere-LINC contact Partial nuclear envelope breakdown is lost in sad1.2 cells Chromosome-LINC interactions control spindle via nuclear envelope regulation