Carvedilol protects the kidneys of tumor-bearing mice without impairing the biodistribution or the genotoxicity of cisplatin
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- 作者：Maria A. Carvalho Rodriguesa ; Neife A.G. dos Santosb ; Marcia C. da Silva Fariac ; Jairo Lisboa Rodriguesc ; Angela Kinoshitad ; Oswaldo Baffad ; Lusania M. Greggi Antunesb ; Fernando Barbosa Jr.b ; Glenda C. Gobee ; Antonio Cardozo dos Santosb ; acsantos@fcfrp.usp.br" class="auth_mail" title="E-mail the corresponding author
- 关键词：Cisplatin ; Carvedilol ; Nephroprotection ; Genotoxicity ; Biodistribution
- 刊名：Chemico-Biological Interactions
- 出版年：2016
- 出版时间：5 February 2016
- 年：2016
- 卷：245
- 期：Complete
- 页码：59-65
- 全文大小：1690 K
文摘
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Carvedilol protects against the nephrotoxicity of cisplatin in tumor-bearing mice.
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Carvedilol does not affect the genotoxicity or biodistribution of cisplatin.
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Carvedilol is not an efficient scavenger of free radicals.
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Carvedilol efficiently chelates ferrous ion.
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The antioxidant mechanism might involve inhibition of the Fenton reaction.