CITED2 Cooperates with ISL1 and Promotes Cardiac Differentiation of Mouse Embryonic Stem Cells

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• 作者：Ivette Pacheco-Leyva¹ ; ² ; Ana Catarina Matias¹ ; ² ; Daniel V. Oliveira¹ ; ² ; Joã ; o M.A. Santos¹ ; ² ; Rita Nascimento¹ ; ² ; Eduarda Guerreiro¹ ; ² ; Anna C. Michell⁴ ; Annebel M. van De Vrugt⁵ ; ⁶ ; ⁷ ; Gisela Machado-Oliveira¹ ; ² ; Guilherme Ferreira⁸ ; Ibrahim Domian⁵ ; ⁶ ; José ; Braganç ; a¹ ; ² ; ³ ; ^{jebraganca@ualg.pt}
• 关键词：transcriptional regulation ; cardiac progenitor ; Cited2 ; Isl1 ; embryonic stem cell ; differentiation
• 刊名：Stem Cell Reports
• 出版年：2016
• 出版时间：13 December 2016
• 年：2016
• 卷：7
• 期：6
• 页码：1037-1049
• 全文大小：2610 K
• 卷排序：7

文摘

Overexpression of CITED2 in ESC promotes cardiogenesis upon differentiation Cited2 depletion reduces ESC ability to generate cardiac cells Cited2 expression is enriched in cardiac progenitors CITED2 and ISL1 cooperate to promote ESC differentiation toward cardiomyocytes