Hesperetin-etoposide combinations induce cytotoxicity in U2OS cells: Implications on therapeutic developments for osteosarcoma

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• 作者：Laura Coutinho^a ; Helena Oliveira^a ; Ana Rita Pacheco^a ; Luis Almeida^b ; Francisco Pimentel^c ; ^d ; Conceiç ; ã ; o Santos^e ; José ; Miguel P. Ferreira de Oliveira^a ; ^e ; ^{oliveira.miguel@ua.pt}
• 关键词：Hesperetin (PubChem CID ; 72281) ; Etoposide (PubChem CID ; 36462) ; Doxorubicin (PubChem ; 32874)
• 刊名：DNA Repair
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：50
• 期：Complete
• 页码：36-42
• 全文大小：1492 K
• 卷排序：50

文摘

Hesperetin is cytotoxic to osteosarcoma U2OS cells and promotes cytostasis. Hesperetin can show additive effects with etoposide to decrease proliferation. The additive combination results in striking G2-phase arrest of the cell cycle.