Clobetasol propionate causes immunosuppression in zebrafish (Danio rerio) at environmentally relevant concentrations

详细信息    查看全文

• 作者：Anita O. Hidasi^a ; ^b ; Ksenia J. Groh^a ; Marc J.-F. Suter^a ; ^c ; Kristin Schirmer^a ; ^b ; ^c ; ^{kristin.schirmer@eawag.ch}
• 关键词：GC ; synthetic glucocorticoid ; GR ; glucocorticoid receptor ; CP ; clobetasol propionate ; WWTP ; wastewater treatment plant ; dpf ; days post fertilization ; hpf ; hours post fertilization ; BCF ; bioconcentration factor ; IS ; internal standard ; LPS ; bacterial lipopolysaccharide ; hpc ; hours post challenge ; DMSO ; dimethyl sulfoxide ; TLR ; toll-like receptor
• 刊名：Ecotoxicology and Environmental Safety
• 出版年：2017
• 出版时间：April 2017
• 年：2017
• 卷：138
• 期：Complete
• 页码：16-24
• 全文大小：781 K
• 卷排序：138

文摘

CP causes significant immunosuppression in zebrafish embryos already at 0.1 nM. Anxa1b, a GR-target gene is significantly down-regulated at 0.05 nM CP. DMSO interferes with the bacterial lipopolysaccharide challenge assay.