Wistar albino rats were used in the study. Blood flow of testis were measured before the torsion (baseline value), before the detorsion and 1 hour after detorsion using Laser Doppler flowmetry. Rats were divided into three groups. Sham group (n = 5): Basal blood flow, flow before detorsion, and flow after detorsion of the testis was determined. Torsion/detorsion group (n = 8): After 2 hours torsion of the testis, blood flow before and after detorsion was determined. Torsion/detorsion + rosuvastatin group (n = 8): After measurement of the basal blood flow, Rosuvastatin (10 mg/kg) was injected intraperitoneally 30 minutes before the detorsion of 2 hour torsion and blood flow before and after detorsion was determined.
There was no significant difference between the the baseline blood flow values of the groups. Blood flow decreased significantly after the torsion. One hour after the detorsion, mean blood flow of the torsion/detorsion + Rosuvastatin group was found significantly higher than the torsion/detorsion group.
Pretreatment with Rosuvastatin before detorsion prevents reperfusion injury induced no-reflow phenomenon after detorsion of testicular torsion.