Farnesoid X receptor-dependent and -independent pathways mediate the transcriptional control of human fibroblast growth factor 19 by vitamin A
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- 作者：Daniel Jahna ; Dominic Sutora ; Donata Dorbatha ; Johannes Weiß ; a ; Oliver Gö ; tzea ; Johannes Schmitta ; 1 ; Heike M. Hermannsa ; Andreas Geiera ; b ; Geier_A2@ukw.de" class="auth_mail" title="E-mail the corresponding author
- 关键词：Fibroblast growth factor 19 ; Farnesoid X receptor ; Bile acid ; Nuclear receptor ; Vitamin A ; Retinoic acid
- 刊名：Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms
- 出版年：2016
- 出版时间：February 2016
- 年：2016
- 卷：1859
- 期：2
- 页码：381-392
- 全文大小：1565 K
文摘
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Vitamin A (VitA) derivatives induce FGF19 expression in human enterocyte-like cells.
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Direct transcriptional activation of FGF19 by VitA is mediated via RARs.
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Direct activation of FGF19 by VitA is independent of the bile acid receptor FXR.
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In addition, VitA indirectly stimulates FGF19 expression via FXR-dependent pathways.