Existence of muscarinic acetylcholine receptor (mAChR) and fibroblast growth factor receptor (FGFR) heteroreceptor complexes and their enhancement of neurite outgrowth in neural hippocampal cultures

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• 作者：V. Di Liberto^a ; ^{valentina.diliberto@unipa.it} ; D.O. Borroto-Escuela^b ; ^c ; ^d ; ^{Dasiel.Borroto.Escuela@ki.se} ; M. Frinchi^a ; ^{monicafrinchi@hotmail.it} ; V. Verdi^a ; ^{vincenzoverdi.bio@libero.it} ; K. Fuxe^b ; ^{Kjell.Fuxe@ki.se} ; N. Belluardo^a ; ¹ ; ^{natale.belluardo@unipa.it} ; G. Mudò ; ^a ; ¹ ; ^{giuseppa.mudo@unipa.it} ; ^{gmudo@tiscali.it}
• 关键词：FGFR1 ; M1 receptor ; Transactivation ; Heteroreceptor complexes ; Neural plasticity
• 刊名：Biochimica et Biophysica Acta (BBA) - General Subjects
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：1861
• 期：2
• 页码：235-245
• 全文大小：1010 K
• 卷排序：1861

文摘

Activation of mAChRs transactivates FGFRs in primary hippocampal neurons. FGFRs are transactivated in a Src-dependent manner. FGFRs phosphorylation correlates with neurite outgrowth. Phosphorylation of FGFRs is fully blocked by M1R antagonist Pirenzepine. M1R-FGFR1 heteroreceptor complexes were identified.