A Heart of Stone: Cardiac Fibroblasts Turn to Bone in Calcified Hearts

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• 作者：Kathryn N. Ivey¹ ; ^{kivey@tenayathera.com}
• 刊名：Cell Stem Cell
• 出版年：2017
• 出版时间：2 February 2017
• 年：2017
• 卷：20
• 期：2
• 页码：151-152
• 全文大小：64 K
• 卷排序：20

文摘

The identity of the cells and molecular events driving deleterious calcification of heart muscle remains elusive. In this issue of Cell Stem Cell, Pillai et al. (2017) report that cardiac fibroblasts respond to injury by adopting an osteogenic cell fate and creating damaging calcific deposits, which can be prevented by inhibiting the activated mineralization process.