Statistical considerations for a chronic bioassay study: Exposure to Decamethylcyclopentasiloxane (D5) and incidence of uterine endometrial adenocarcinomas in a 2-year inhalation study with Fischer rats
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- 作者：Linda J. Younga ; LJYoung@ufl.edu" class="auth_mail" title="E-mail the corresponding author ; Peter Morfeldb ; c
- 关键词：Decamethylcyclopentasiloxane D5 ; Adenocarcinoma ; Rat experiment ; Statistical analysis ; Probit model ; Max poly-k trend test ; Fisher exact test ; Exact logistic regression
- 刊名：Regulatory Toxicology and Pharmacology
- 出版年：2016
- 出版时间：February 2016
- 年：2016
- 卷：74
- 期：supp_S
- 页码：S14-S24
- 全文大小：449 K
文摘
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60 Fischer-344 female rats were exposed to D5 levels: of 0, 10, 40, and 160 ppm.
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Incidence of endometrial uterine adenocarcinomas was analyzed.
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Number of cases: 0, 1, 0, and 5 per dose group, respectively.
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D5 exposure was significant or borderline significant compared to all control sets.
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Whether the high dose group was included in an analysis affected significance.