Effectiveness of minocycline and FK506 alone and in combination on enhanced behavioral and biochemical recovery from spinal cord injury in rats
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- 作者：Mohammad Ahmada ; mbadshah@ksu.edu.sa" class="auth_mail" title="E-mail the corresponding author ; Abdulrahim Zakariab ; Khalid M. Almutairic
- 关键词：Spinal cord injury ; Behavioral activity ; Histopathology ; Oxidative stress ; Monoamine neurotransmitters ; Cocktail drug therapy
- 刊名：Pharmacology Biochemistry and Behavior
- 出版年：2016
- 出版时间：June 2016
- 年：2016
- 卷：145
- 期：Complete
- 页码：45-54
- 全文大小：1380 K
文摘
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Minocycline and FK506 in combination as well as individually were tested in SCI rats.
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All behavioral motor functions improved in SCI animals due to drugs treatment.
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Histopathological recovery was observed due to drugs treatment in the SCI animals.
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Neurotransmitters and oxidative stress were also improved in the SCI tissues.
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Recovery was in the order of FK506 + minocycline > minocycline > FK506 throughout.