Single dose efficacy evaluation of two partial benzodiazepine receptor agonists in photosensitive epilepsy patients: A placebo-controlled pilot study
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- 作者：Dorothé ; e G.A. Kasteleijn-Nolst Trenité ; a ; b ; Rolf H.H. Groenwoldc ; Bernd Schmidtd ; Wolfgang Lö ; schere ; f ; wolfgang.loescher@tiho-hannover.de" class="auth_mail" title="E-mail the corresponding author
- 关键词：Beta-carboline ; GABA ; Anxiety ; EEG ; Photosensitivity ; Abecarnil ; Flumazenil
- 刊名：Epilepsy Research
- 出版年：2016
- 出版时间：May 2016
- 年：2016
- 卷：122
- 期：Complete
- 页码：30-36
- 全文大小：1028 K
文摘
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The clinical use is of benzodiazepines (BZDs) is limited due to adverse effects.
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Partial or subtype selective agonists at the BZD receptor may have advantages.
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One of these compounds, abecarnil, exerts anxiolytic activity in patients.
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Here, we compared abecarnil and flumazenil in patients with photosensitive epilepsy.
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Abecarnil was antiepileptic and significantly differed from both placebo and flumazenil.