Extended substrate specificity and first potent irreversible inhibitor/activity-based probe design for Zika virus NS2B-NS3 protease

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• 作者：Wioletta Rut^a ; Linlin Zhang^b ; ^c ; Paulina Kasperkiewicz^a ; ^d ; Marcin Poreba^a ; ^d ; Rolf Hilgenfeld^b ; ^c ; Marcin Drąg^a ; ^{marcin.drag@pwr.edu.pl}
• 关键词：Irreversible inhibitor ; Proteolytic enzyme ; ZIKA ; Substrate specificity
• 刊名：Antiviral Research
• 出版年：2017
• 出版时间：March 2017
• 年：2017
• 卷：139
• 期：Complete
• 页码：88-94
• 全文大小：1359 K
• 卷排序：139

文摘

A very active fluorogenic substrate was identified. Irreversible inhibitor for ZIKA virus NS2B-NS3 protease was designed. Potential structure of activity-based probe is reported.