Highly efficient NMR enantiodiscrimination of 1,1,1,3,3-pentafluoro-2-(fluoromethoxy)-3-methoxypropane, a chiral degradation product of sevoflurane, by heptakis(2,3-di-O-acetyl-6-O-tert-butyldimethylsilyl)-;2;-cyclodextrin
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- 作者：Gloria Uccello-Barretta ; Giuseppe Sicoli ; Federica Balzano ; Volker Schurig and Piero Salvadori
- 刊名：Tetrahedron: Asymmetry
- 出版年：2006
- 出版时间：2 October 2006
- 年：2006
- 卷：17
- 期：17
- 页码：2504-2510
- 全文大小：352 K
文摘
The molecular basis of the efficient enantiodiscrimination of 1,1,1,3,3-pentafluoro-2-(fluoromethoxy)-3-methoxypropane, a chiral degradation product of the inhalation anaesthetic sevoflurane, using heptakis(2,3-di-O-acetyl-6-O-tert-butyldimethylsilyl)-;2;-cyclodextrin as chiral selector, has been investigated by NMR spectroscopy. An interaction mechanism is proposed, which highlights the role of the functional groups on the ;2;-cyclodextrin rims in addition to a partial molecular inclusion.