Improvement of stability of phenacyloxycarbamidomethyl (Pocam) group, a cysteine protecting group removable with zinc reduction, under acidic conditions

详细信息    查看全文

• 作者：Hidekazu Katayama ; ^{katay@tokai-u.jp} ; Takuma Goto
• 关键词：Pocam ; Solid-phase peptide synthesis ; Thioester method ; Thiol protecting group
• 刊名：Tetrahedron Letters
• 出版年：2017
• 出版时间：15 February 2017
• 年：2017
• 卷：58
• 期：7
• 页码：610-613
• 全文大小：571 K
• 卷排序：58

文摘

A novel Cys protecting group, Tfe-Pocam group, was developed. This protecting group was almost completely stable in TFA solution. It could be used in Fmoc-SPPS and peptide condensation reactions. It was applicable to the regioselective disulfide bond formation reactions.