Differential expression of sema3A and sema7A in a murine model of multiple sclerosis: Implications for a therapeutic design
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- 作者：Ana Gutié ; rrez-Francoa ; b ; 1 ; 2 ; agutierrez@igtp.cat" class="auth_mail" title="E-mail the corresponding author ; Carme Costaa ; b ; 1 ; carme.costa@vhir.org" class="auth_mail" title="E-mail the corresponding author ; Herena Eixarcha ; b ; 1 ; herena.eixarch@vhir.org" class="auth_mail" title="E-mail the corresponding author ; Mireia Castilloa ; b ; mireia.castillo@vhir.org" class="auth_mail" title="E-mail the corresponding author ; Eva M. Medina-Rodrí ; guezc ; emedinar@sescam.jccm.es" class="auth_mail" title="E-mail the corresponding author ; Ana Bribiá ; nc ; d ; abribian@cajal.csic.es" class="auth_mail" title="E-mail the corresponding author ; Fernando de Castroc ; d ; fdecastro@cajal.csic.es" class="auth_mail" title="E-mail the corresponding author ; Xavier Montalbana ; b ; xavier.montalban@cem-cat.org" class="auth_mail" title="E-mail the corresponding author ; Carmen Espejoa ; b ; carmen.espejo@vhir.org" class="auth_mail" title="E-mail the corresponding author
- 关键词：BSA ; bovine serum albumin ; CNS ; central nervous system ; CFA ; complete Freund's adjuvant ; DAB ; 3 ; 3&prime ; -diaminobenzidine ; EAE ; experimental autoimmune encephalomyelitis ; FBS ; foetal bovine serum ; GPI ; glycophosphatidylinositol ; GM ; grey matter ; HE ; haematoxylin and eosin ; KB ; Klü ; ver&ndash ; Barrera ; MS ; multiple sclerosis ; MOG ; myelin oligodendrocyte glycoprotein ; nTreg ; natural regulatory T cells ; NDS ; normal donkey serum ; OPC ; oligodendrocyte precursor cell ; PFA ; paraformaldehyde ; PPIB ; pe
- 刊名：Clinical Immunology
- 出版年：2016
- 出版时间：February 2016
- 年：2016
- 卷：163
- 期：Complete
- 页码：22-33
- 全文大小：2310 K
文摘
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The expression of sema3A, 7A and its receptors is increased in the CNS of EAE-mice.
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Sema7A increases in both infiltrating CNS and peripheral immune cells.
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Sema3A shows a different pattern in the peripheral and infiltrating immune cells.
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Sema3A and 7A are expressed in neonatal and adult OPCs and in mature oligodendrocytes.
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Sema7A may represent a potential therapeutic target for the treatment of MS.