Effects of serum immunoglobulins from patients with complex regional pain syndrome (CRPS) on depolarisation-induced calcium transients in isolated dorsal root ganglion (DRG) neurons
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- 作者：Joanne M. Reillya ; 1 ; Backialakshmi Dharmalingama ; b ; 2 ; Stephen J. Marsha ; Victoria Thompsonb ; 3 ; Andreas Goebelb ; 4 ; andreasgoebel@rocketmail.com" class="auth_mail" title="E-mail the corresponding author ; David A. Browna ; 4
- 关键词：CaV ; voltage-gated calcium channel ; CRPS ; complex regional pain syndrome ; Ctx ; ώ-contoxin GVIA ; DRG ; dorsal root ganglion ; FBS ; foetal bovine serum ; IgG ; immunoglobulin ; IS ; inflammatory mediator pre-incubation &ldquo ; soup&rdquo ; (1 ; μM each of histamine ; 5-hydroxytryptamine ; bradykinin and prostaglandin E2)NGF ; nerve growth factor ; Nif ; nifedipine ; Bay ; BAY K8644 ; PBS ; phosphate-buffered saline solution ; PE ; phenylephrine ; PGE2 ; prostaglandin E2
- 刊名：Experimental Neurology
- 出版年：2016
- 出版时间：March 2016
- 年：2016
- 卷：277
- 期：Complete
- 页码：96-102
- 全文大小：756 K
文摘
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Complex regional pain syndrome (CRPS) may have an auto-immune component.
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Patient-mmunoglobulins (IgG) were tested against depolarisation-induced calcium transients in nociceptive sensory neurons.
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When neurons were pre-treated with inflammatory mediators, one such IgG substantially and significantly reduced transients.
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Such pretreatment also facilitated depression of the calcium transient by the alpha-1 adrenoceptor agonist phenylephrine.
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This could accord with the possibility of an auto-immune reaction against sensory neuron alpha-1 adrenoceptor.