St. John’s wort extract and hyperforin inhibit multiple phosphorylation steps of cytokine signaling and prevent inflammatory and apoptotic gene induction in pancreatic β cells

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• 作者：Michela Novelli^a ; ¹ ; ^{michela.novelli@med.unipi.it} ; Marta Menegazzi^b ; ¹ ; ^{marta.menegazzi@univr.it} ; Pascale Beffy^c ; ¹ ; ^{pascale.beffy@ifc.cnr.it} ; Svetlana Porozov^a ; ^{svetlana.porozov@hotmail.com} ; Alex Gregorelli^b ; ^{alex.gregorelli@gmail.com} ; Daniela Giacopelli^c ; ^{danielagiacopelli@hotmail.it} ; Vincenzo De Tata^a ; ^{vincenzo.detata@med.unipi.it} ; Pellegrino Masiello^a ; ^{pellegrino.masiello@med.unipi.it} ; ^{rinomasiello@hotmail.com}
• 关键词：BAD ; BCL2-associated agonist of cell death ; BIM ; BCL2-like 11 ; CHOP ; C/EBP homologous protein ; CIITA ; Class II major histocompatibility complex transactivator ; COX2 ; Cyclo-oxygenase 2 ; DP5 ; Death protein 5 ; EMSA ; Electrophoretic mobility shift assay ; ER ; Endoplasmic reticulum ; ERK ; Extracellular signal-regulated kinase ; FOXO1 ; Forkhead box O1 ; HPF ; Hyperforin ; ICAM1 ; Intercellular adhesion molecule 1 ; IFN-γ ; Interferon gamma ; IκB ; Inhibitor of kappa-B ; IKK ; NF-kappaB inhibitory subunit IkappaB k
• 刊名：The International Journal of Biochemistry & Cell Biology
• 出版年：2016
• 出版时间：December 2016
• 年：2016
• 卷：81
• 期：part_PA
• 页码：92-104
• 全文大小：3654 K
• 卷排序：81

文摘

St. John’s wort extract (SJW) and hyperforin (HPF) block cytokine effects in β cells. SJW and HPF simultaneously inhibit cytokine-induced STAT-1, NF-κB and MAPK activation. SJW and HPF hinder multiple phosphorylation steps of signaling pathways. SJW and HPF prevent induction of inflammatory and apoptotic cytokine target genes. These natural compounds are exploitable for prevention of immune-mediated β-cell loss.