The Role of Transient Receptor Potential Cation Channel, Subfamily C, Member 1 in the Odontoblast-like Differentiation of Human Dental Pulp Cells

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• 作者：Zhi Song ; PhD^&lowast ; ; ^&dagger ; ; Lingling Chen ; PhD^&lowast ; ; ^&dagger ; ; Jia Guo ; PhD^&lowast ; ; ^&dagger ; ; Wei Qin ; PhD^&lowast ; ; ^&dagger ; ; Runfu Wang ; PhD^&lowast ; ; ^&dagger ; ; Shuheng Huang ; PhD^&lowast ; ; ^&dagger ; ; Xiaoting Yang ; PhD^&lowast ; ; ^&dagger ; ; Yaguang Tian ; PhD^&Dagger ; ; ^{yaguangtian@163.com} ; Zhengmei Lin ; PhD^&lowast ; ; ^&dagger ; ; ^{linzhm@mail.sysu.edu.cn}
• 关键词：Calcium ; cell differentiation ; odontoblast ; reparative dentin formation ; transient receptor potential cation channel ; subfamily C ; member 1
• 刊名：Journal of Endodontics
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：43
• 期：2
• 页码：315-320
• 全文大小：1151 K
• 卷排序：43

文摘

Transient receptor potential cation channel, subfamily C, member 1 (TRPC1) exerted important roles in controlling odontoblastlike differentiation. Down-regulation of TRPC1 attenuated odontoblastlike differentiation. Knockdown of TRPC1 decreased calcium ion entry to the cytoplasm of human dental pulp cells. TRPC1 may be a potential therapeutic target for regenerative endodontics.