Mutan: A mixed linkage α-[(1,3)- and (1,6)]-d-glucan from Streptococcus mutans, that induces osteoclast differentiation and promotes alveolar bone loss
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- 作者：Hyun-Jung Kwona ; b ; Jung Min Kimc ; Kook-Il Hana ; Eui-Gil Junga ; Yong Hyun Kima ; Bharat Bhusan Patnaika ; d ; Mi Sook Yoone ; Sung Kyun Chunge ; Wan Jong Kima ; Man-Deuk Hana ; mdhan@sch.ac.kr" class="auth_mail" title="E-mail the corresponding author
- 关键词：Isoflurane (PubChem CID ; 3763) ; Sodium tartarate (PubChem CID ; 13355) ; Dimethylsulfoxide (PubChem CID ; 679) ; MTT formazan (PubChem CID ; 16218671) ; Deuterium oxide (PubChem CID ; 24602) ; Potassium bromide (PubChem CID ; 253877) ; Trichloroacetic acid (PubChem CID ; 6421)
- 刊名：Carbohydrate Polymers
- 出版年：2016
- 出版时间：10 February 2016
- 年：2016
- 卷：137
- 期：Complete
- 页码：561-569
- 全文大小：2146 K
文摘
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Mutan, an extracellular α-[(1,3)- and (1,6)]-d-glucan from S. mutans was studied.
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Mutan can inhibit intra-cortical remodelling in the rat maxilla.
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Mutan activates osteoclast differentiation and alveolar bone loss in rat maxillae.
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Mutan leads to five-fold expression of proinflammatory cytokines in RAW264.7 cells.