Investigating the Efficacy of Subharmonic Aided Pressure Estimation for Portal Vein Pressures and Portal Hypertension Monitoring

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• 作者：Jaydev K. Dave ; Valgerdur G. Halldorsdottir ; John R. Eisenbrey ; Daniel A. Merton ; Ji-Bin Liu ; Jian-Hua Zhou ; Hsin-Kai Wang ; Suhyun Park ; Scott Dianis ; Carl L. Chalek ; Feng Lin ; Kai E. Thomenius ; Daniel B. Brown ; Flemming Forsberg
• 关键词：Portal hypertension ; Subharmonic-aided pressure estimation ; Noninvasive pressure estimation ; Ultrasound contrast agents ; Subharmonic imaging
• 刊名：Ultrasound in Medicine and Biology
• 出版年：2012
• 出版时间：October, 2012
• 年：2012
• 卷：38
• 期：10
• 页码：1784-1798
• 全文大小：1193 K

文摘

The efficacy of using subharmonic emissions from Sonazoid microbubbles (GE Healthcare, Oslo, Norway) to track portal vein pressures and pressure changes was investigated in 14 canines using either slow- or high-flow models of portal hypertension (PH). A modified Logiq 9 scanner (GE Healthcare, Milwaukee, WI, USA) operating in subharmonic mode (f_transmit: 2.5 MHz, f_receive: 1.25 MHz) was used to collect radiofrequency data at 10-40 % incident acoustic power levels with 2-4 transmit cycles (in triplicate) before and after inducing PH. A pressure catheter (Millar Instruments, Inc., Houston, TX, USA) provided reference portal vein pressures. At optimum insonification, subharmonic signal amplitude changes correlated with portal vein pressure changes; r?ranged from ?0.82 to ?0.94 and from ?0.70 to ?0.73 for PH models considered separately or together, respectively. The subharmonic signal amplitudes correlated with absolute portal vein pressures (r: ?0.71 to ?0.79). Statistically significant differences between subharmonic amplitudes, before and after inducing PH, were noted (p ¡Ü 0.01). Portal vein pressures estimated using subharmonic aided pressure estimation did not reveal significant differences (p > 0.05) with respect to the pressures obtained using the Millar pressure catheter. Subharmonic-aided pressure estimation may be useful clinically for portal vein pressure monitoring.