Correlation of quantified contrast-enhanced power Doppler ultrasonography with immunofluorescent analysis of microvessel density in spontaneous canine tumours
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- 作者：Stefanie Ohlerth ; Melanie Wergin ; Carla Rohrer Bley ; Francesca Del Chicca ; Dagmar Laluhová ; Beat Hauser ; Malgorzata Roos ; Barbara Kaser-Hotz
- 关键词：Doppler ultrasound ; Microvessel density ; Tumours ; Canine
- 刊名：The Veterinary Journal
- 出版年：2010
- 出版时间：January 2010
- 年：2010
- 卷：183
- 期：1
- 页码：58-62
- 全文大小：291 K
文摘
Conventionally, tumour vascularity is assessed invasively by immunofluorescent analysis. Quantified contrast-enhanced power Doppler ultrasound has been used to measure tumour angiogenesis non-invasively in humans and experimental animals. The purpose of this study was to correlate quantified contrast-enhanced power Doppler ultrasound with immunofluorescent results in 45 spontaneous canine tumours. With power Doppler, mean vascularity was high in squamous cell carcinomas, moderate in malignant oral melanomas and low in sarcomas. There was high mean vascularity in squamous cell carcinomas and low mean vascularity in sarcomas and malignant oral melanomas. Although Doppler parameters correlated moderately with microvascular density for all tumours (P = 0.004, r = 0.4), they did not correlate within histology groups. These analyses show that vascularity differs among canine tumour histology groups. However, dependent on the method used, measurement of tumour vascularity can provide different biological information.