A potential role for adiponectin receptor 2 (AdipoR2) in the regulation of alcohol intake
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- 作者：Vez Repunte-Canonigo ; Fulvia Berton ; Pietro Cottone ; Anne Reifel-Miller ; Am ; a J. Roberts ; Marisela Morales ; Walter Francesconi ; Pietro Paolo Sanna
- 关键词：Neural plasticity ; PI3K Jak/Stat ; ERK ; MAPK ; Adipokine ; Acrp30 ; apM1
- 刊名：Brain Research
- 出版年：2010
- 出版时间：21 June 2010
- 年：2010
- 卷：1339
- 期：Complete
- 页码：11-17
- 全文大小：702 K
文摘
The anterior cingulate cortex (ACC) has been implicated in alcohol and drug addiction. We recently identified the small G protein K-ras as an alcohol-regulated gene in the ACC by gene expression analysis. We show here that the adiponectin receptor 2 (AdipoR2) was differentially regulated by alcohol in the ACC in a K-ras-dependent manner. Additionally, withdrawal-associated increased drinking was attenuated in AdipoR2 null mice. Intracellular recordings revealed that adiponectin increased the excitability of ACC neurons and that this effect was more pronounced during alcohol withdrawal, suggesting that AdipoR2 signaling may contribute to increased ACC activity. Altogether, the data implicate K-ras-regulated pathways involving AdipoR2 in the cellular and behavioral actions of alcohol that may contribute to overactivity of the ACC during withdrawal and excessive alcohol drinking.