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Indoleamine-2,3-dioxygenase mediates neurobehavioral alterations induced by an intracerebroventricular injection of amyloid-βb>1-42b> peptide in mice
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文摘
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Intracerebroventricular injection of Aβb>1-42b> induced memory and emotional disturbances.

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b>1-42b> elicits neuroinflammation and neurotrophic deficiency in brain of mice.

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b>1-42b> increased indoleamine-2,3-dioxygenase activity in brain of mice.

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b>1-42b> increased tryptophan levels and kynurerine/tryptophan ratio in brain of mice.

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Indoleamine-2,3-dioxigenase mediates behavioral disturbances induced by Aβb>1-42.b>

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